I just started Apriso today and am in the middle of a bad flare (UC). I am having a lot of blood and am also using Rowasa enemas for the bottom part of my colon, which works well but doesn't get up high enough for my current flare. I am really scared because my UC flares are usually much shoprter than this one and not as severe - cramping and a lot of blood. Also, I have only used oral meds once a long time ago (11 or 12 yrs. ago) as my flares are not usually this bad at all. If anyone else has used Apriso, please let me know if it helped and how long before you noticed results. I am getting really frustrated and worried. Thanks in advance for your help and support!!!