I had a terrible crohns flare in March of this year. Ended up in the hospital with a huge perianal abscess and fistulas. I had seton placement surgery along with antibiotics and steroids. A few weeks later they started me on remicade. Initially, even after the seton surgery, I had terrible pain at the abscess site with immense drainage. After the first and second doses of remicade the pain and drainage lessened. Since then though, it has been a rollarcoaster of manageable pain one day and horrific pain the next. I get regular checks with the CRS who says the fistulas are draining fine-everything just hurts because they keep refilling. For awhile I went on various antibiotics (including cipro, flagyl, Zithromax, doxycycline) that seemed to do nothing. I am also on the GAPS diet and am 100% strict. I have zero intestinal symptoms. The abscess pain and drainage will be manageable if I rest a ton. But the minute I try to be active like a normal person (running errands, etc.) I suffer terribly the next day. It is impossible to rest in bed all the time as I am young and I have a 1 year old and I need to live a somewhat normal life. I'm so tired of this pain. Today I saw the CRS and she suggested we talk to my gastro about adding something like Imuran to the remicade. I really don't want to increase my cancer risk and I'm just hoping eventually this diet kicks in and I don't even know if the remicade has worked past the second dose. I feel like I just need to mentally prepare for the bag. I feel so hopeless and tired of pain. Any suggestions?