Trial fail for ozanimod

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About Zeposia (ozanimod)
Zeposia (ozanimod) is an oral, sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity to S1P receptors 1 and 5. Zeposia blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which Zeposia exerts therapeutic effects in Crohn’s disease is unknown but may involve the reduction of lymphocyte migration into the gut.

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works by blocking white blood cells from getting into the blood, ie, hampering the immune system. sounds okay for emergency use, but long term problems not unlikely. had to look up info on pbl to see what they do

https://www.nature.com/articles/s41598-019-44677-3
Peripheral blood lymphocytes (PBLs) are mature lymphocytes that circulate in the blood rather than being localized to organs. They are one of several types of white blood cells (WBCs) that are crucial for the immune system.
 
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