Canadian medical research breakthrough - Gut bacteria combination shows risk for Crohn's disease

[J100]

https://www.newswire.ca/news-releas...shows-risk-for-crohn-s-disease-849544080.html
I watched the youtube video and they claim that this is ground breaking. Let's hope it can result in newer treatments which are safer with potentially less adverse impacts.

 

[wild_one353]

I like this! Although they might be overselling it a bit when they said something like its the only project that matters and so forth. then one page says they are tracking bacteria and another says they are using blood samples, kinda weird. Also it says they study started in 2008, that was 15 years ago!!

 

[J100]

It is possible that they may be overselling it. As I have said, this by itself has to lead to a successful clinical trials of newer medications. I think the reason it took so long was because they actually monitored healthy relatives along with the people who had Crohn's or went on to develop Crohn's.
Canada has had a good record in research. There are newer ways being worked upon to balance the gut microbiome. Let's hope for the best. That's all we can do.

 

[wduk]

https://www.newswire.ca/news-releas...shows-risk-for-crohn-s-disease-849544080.html
I watched the youtube video and they claim that this is ground breaking. Let's hope it can result in newer treatments which are safer with potentially less adverse impacts.

Am I blind or did the article not mention which bacteria have been identified as possible problem combinations?

 

[asadmom]

Am I blind or did the article not mention which bacteria have been identified as possible problem combinations?

You are not blind. That is the first question I thought of when I read the article. To start - disclose the list of the offending bacteria. Put people on EEN and observe the population of the bacteria in all the people. Then, we talk.

 

[wduk]

You are not blind. That is the first question I thought of when I read the article. To start - disclose the list of the offending bacteria. Put people on EEN and observe the population of the bacteria in all the people. Then, we talk.

I did some digging and found the data:


Results
In the validation cohort, the microbiome risk score (MRS) model yielded a hazard ratio of 2.24 (95% confidence interval, 1.03-4.84; P = .04), using the median of the MRS from the discovery cohort as the threshold. The MRS demonstrated a temporal validity by capturing individuals that developed CD up to 5 years before disease onset (area under the curve > 0.65). The 5 most important taxa contributing to the MRS included Ruminococcus torques, Blautia, Colidextribacter, an uncultured genus-level group from Oscillospiraceae, and Roseburia.

https://www.sciencedirect.com/science/article/abs/pii/S0016508523008053